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KMID : 0617320010100010052
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.52 ~ p.54
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Cytotoxic Constituents of Psoralea corylifolia
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Mar, Woongchon
Je, Kang-Hun/Seo, Eun-Kyoung
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Abstract
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A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L.(Leguminosae) with the IC_50 values of 0.3 and 0.4㎍/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541(lung) and HepG2 (liver hepatoma) cancer cell lines.
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